CAPN1

Across TCGA patient cohorts, CAPN1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN1-associated genes across cancer lineages are c-Kit, Acetyl-a-Tubulin-Lys40, and PCNA. Each is linked with CAPN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CAPN1-to-partner and partner-to-CAPN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by CAPN1-low versus CAPN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN1→partner) and Y-score (partner→CAPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Kit →	-0.187	-1.736	.020	.007	3	3
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.479	+1.736	.006	.007	3	2
UCEC	PCNA →	+0.248	+1.906	<.001	.015	3	2
UCEC	Rab25 →	-0.337	-2.584	.003	.010	3	2
UCEC	Rad50 →	-0.204	-1.736	.015	.007	3	2
UCEC	Src_pY527 →	-0.301	-2.321	.043	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

c-Kit by CAPN1 expression — UCEC

Explore this box plot interactively →