CAPN1

Across TCGA cell cohorts, CAPN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,853 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAPN1-associated GO terms across cancer lineages are Negative regulation of supramolecular fiber organization, NMDA selective glutamate receptor signaling pathway, and Small GTPase-mediated signal transduction. Each is linked with CAPN1 in more than 16 cancer types. Because this analysis shows association rather than direction, both CAPN1-to-partner and partner-to-CAPN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of supramolecular fiber organization grouped by CAPN1-low versus CAPN1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN1→partner) and Y-score (partner→CAPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of supramolecular fiber organization →	+0.124	+1.855	<.001	<.001	3	17
URINARY_TRACT	NMDA selective glutamate receptor signaling pathway →	+0.266	+1.632	<.001	<.001	3	15
OESOPHAGUS	Small GTPase-mediated signal transduction →	+0.080	+1.852	.002	<.001	3	15
OESOPHAGUS	Rho protein signal transduction →	+0.170	+1.764	.001	.002	3	14
URINARY_TRACT	Protein localization to cell-cell junction →	+0.188	+1.719	<.001	<.001	3	14
LARGE_INTESTINE	Protein localization to membrane →	+0.065	+1.111	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,853 associations by consensus.

Negative regulation of supramolecular fiber organization by CAPN1 expression — URINARY_TRACT

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