CAPG

Across TCGA patient cohorts, CAPG mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPG-associated genes across cancer lineages are IGFBP2, JNK2, and Ku80. Each is linked with CAPG in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPG-to-partner and partner-to-CAPG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by CAPG-low versus CAPG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPG→partner) and Y-score (partner→CAPG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.787	-2.459	.012	.020	3	1
UCEC	JNK2 →	+0.321	+3.009	<.001	.019	3	1
UCEC	Ku80 →	+0.357	+2.472	.001	.011	3	1
UCEC	PRAS40_pT246 →	+0.170	+3.000	.040	.036	3	1
UCEC	Rad50 →	-0.328	-2.459	.005	.020	3	1
UCEC	SETD2 →	-0.218	-2.459	.038	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

IGFBP2 by CAPG expression — UCEC

Explore this box plot interactively →