CAP2

Across TCGA patient cohorts, CAP2 mutation is significantly associated with the RNA expression of many other genes, with 1,349 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAP2-associated genes across cancer lineages are TIAM1, RNA5SP147, and MTND3P20. Each is linked with CAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAP2-to-partner and partner-to-CAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIAM1 grouped by CAP2-low versus CAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAP2→partner) and Y-score (partner→CAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIAM1 →	-0.734	-2.382	<.001	.003	3	2
BRCA	RNA5SP147 →	+0.242	+5.324	<.001	.003	3	2
HNSC	MTND3P20 →	+0.412	+8.366	<.001	<.001	3	2
UCEC	IFI6 →	-1.658	-2.807	<.001	.003	3	2
COAD	SMSP1 →	+0.160	+3.646	<.001	.009	3	2
COAD	OSBPL9P5 →	+0.362	+6.149	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,349 associations by consensus.

TIAM1 by CAP2 expression — UCEC

Explore this box plot interactively →