CAP1

Across TCGA patient cohorts, CAP1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAP1-associated genes across cancer lineages are PCNA, Bax, and eEF2. Each is linked with CAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAP1-to-partner and partner-to-CAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CAP1-low versus CAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAP1→partner) and Y-score (partner→CAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.214	+1.502	.007	.030	3	2
UCEC	Bax →	+0.234	+1.502	.007	.030	3	2
UCEC	eEF2 →	+0.400	+2.700	.002	.005	3	1
UCEC	A-Raf_pS299 →	-0.179	-3.807	<.001	<.001	3	1
UCEC	ERK2 →	+0.212	+1.502	.002	.030	3	1
UCEC	GAPDH →	+0.524	+2.584	.007	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

PCNA by CAP1 expression — UCEC

Explore this box plot interactively →