CAND2

Across TCGA patient cohorts, CAND2 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAND2-associated genes across cancer lineages are AR, 4E-BP1, and E-Cadherin. Each is linked with CAND2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CAND2-to-partner and partner-to-CAND2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AR grouped by CAND2-low versus CAND2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAND2→partner) and Y-score (partner→CAND2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	AR →	+0.329	+2.820	<.001	.035	2	3
COAD	4E-BP1 →	+0.278	+3.000	.004	.035	3	2
COAD	E-Cadherin →	-0.697	-2.313	.014	.035	3	2
UCEC	MSH2 →	-0.247	-1.739	<.001	.012	3	2
UCEC	mTOR_pS2448 →	-0.107	-1.401	.015	.041	3	2
UCEC	p21 →	+0.117	+1.335	.041	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

AR by CAND2 expression — COAD

Explore this box plot interactively →