CAND1

Across TCGA patient cohorts, CAND1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAND1-associated genes across cancer lineages are GAPDH, INPP4B, and 4E-BP1. Each is linked with CAND1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CAND1-to-partner and partner-to-CAND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by CAND1-low versus CAND1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAND1→partner) and Y-score (partner→CAND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.361	+1.807	.024	.024	3	3
LUAD	INPP4B →	-0.498	-2.983	.033	.036	2	3
LUAD	4E-BP1 →	+0.556	+2.820	<.001	.035	2	3
COAD	14-3-3_beta →	-0.198	-2.961	.032	.035	3	2
COAD	PCNA →	+0.323	+2.330	.003	.020	2	3
COAD	cIAP →	+0.160	+2.381	.005	.018	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

GAPDH by CAND1 expression — UCEC

Explore this box plot interactively →