CAND1

Across TCGA cell cohorts, CAND1 mutation is significantly associated with the RNA expression of many other genes, with 333 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAND1-associated genes across cancer lineages are PRR27, MSGN1, and CYP11B2. Each is linked with CAND1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAND1-to-partner and partner-to-CAND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR27 grouped by CAND1-low versus CAND1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAND1→partner) and Y-score (partner→CAND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRR27 →	+0.088	+2.054	<.001	.008	3	2
SKIN	MSGN1 →	+0.045	+4.022	<.001	.006	3	1
STOMACH	CYP11B2 →	+0.005	+4.285	<.001	.007	3	1
STOMACH	BOD1L2 →	+0.005	+4.285	<.001	.007	3	1
STOMACH	GOLGA6L6 →	+0.064	+4.794	<.001	.001	3	1
LARGE_INTESTINE	GNPNAT1 →	+0.603	+2.451	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 333 associations by consensus.

PRR27 by CAND1 expression — LARGE_INTESTINE

Explore this box plot interactively →