CAMKK1

Across TCGA patient cohorts, CAMKK1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAMKK1-associated genes across cancer lineages are Cyclin-B1, EGFR_pY1068, and JNK2. Each is linked with CAMKK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAMKK1-to-partner and partner-to-CAMKK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CAMKK1-low versus CAMKK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAMKK1→partner) and Y-score (partner→CAMKK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.424	+3.584	.029	.002	3	2
UCEC	EGFR_pY1068 →	-0.198	-1.440	.023	.024	3	1
UCEC	JNK2 →	+0.229	+2.611	<.001	.005	3	1
UCEC	Ku80 →	+0.182	+1.453	.026	.015	3	1
UCEC	MEK1 →	+0.345	+3.000	.006	<.001	3	1
UCEC	PCNA →	+0.194	+2.070	.009	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Cyclin-B1 by CAMKK1 expression — UCEC

Explore this box plot interactively →