CALU

Across TCGA patient cohorts, CALU mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALU-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and A-Raf_pS299. Each is linked with CALU in more than 1 cancer types. Because this analysis shows association rather than direction, both CALU-to-partner and partner-to-CALU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CALU-low versus CALU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALU→partner) and Y-score (partner→CALU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.111	-3.143	.011	.018	3	1
UCEC	EGFR_pY1068 →	-0.276	-2.115	.011	.019	3	1
UCEC	A-Raf_pS299 →	-0.171	-3.459	.001	.005	2	2
UCEC	ACC_pS79 →	+0.330	+2.999	.029	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.193	-2.102	.008	.019	3	1
UCEC	Notch1 →	+0.147	+2.115	.017	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

14-3-3_beta by CALU expression — UCEC

Explore this box plot interactively →