CALR

Across TCGA pan-cancer cohorts, CALR mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CALR data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CALR mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CALR expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

CCRCC, LSCC, and GBM are the cancer types where CALR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.204	0.695	<.001	61	view →
LSCC	DFS	Tertile	II,III,IV	0.500	0.877	.004	19	view →
GBM	DFS	Median	All	0.258	0.459	.003	11	view →
LUAD	DFS	Quartile	III,IV	1.000	0.422	.024	6	view →
PDAC	DFS	Quartile	II,III,IV	0.853	0.663	.013	4	view →
HNSC	OS	Tertile	II,III,IV	0.563	0.804	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CALR–CCRCC (DFS)

Open the CCRCC breakdown →