CALR

Across TCGA patient cohorts, CALR mutation is significantly associated with the RNA expression of many other genes, with 1,018 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALR-associated genes across cancer lineages are ATXN3L, RNU6-1029P, and ATP5MGP7. Each is linked with CALR in more than 1 cancer types. Because this analysis shows association rather than direction, both CALR-to-partner and partner-to-CALR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATXN3L grouped by CALR-low versus CALR-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALR→partner) and Y-score (partner→CALR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	ATXN3L →	+0.042	+6.837	<.001	<.001	3	2
LIHC	RNU6-1029P →	+0.333	+4.776	<.001	.003	3	2
CESC	ATP5MGP7 →	+0.220	+5.812	<.001	.003	3	2
LUSC	TRBV17 →	+0.130	+4.548	.006	.009	3	2
LIHC	ZACNP1 →	+0.042	+6.914	<.001	<.001	3	1
UCEC	EIF3M →	+0.470	+1.939	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,018 associations by consensus.

ATXN3L by CALR expression — CESC

Explore this box plot interactively →