CALR

Across TCGA patient cohorts, CALR mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALR-associated genes across cancer lineages are 14-3-3_beta, FoxM1, and JNK_pT183_Y185. Each is linked with CALR in more than 1 cancer types. Because this analysis shows association rather than direction, both CALR-to-partner and partner-to-CALR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CALR-low versus CALR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALR→partner) and Y-score (partner→CALR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.147	-2.794	<.001	.003	3	1
UCEC	FoxM1 →	+0.248	+3.179	.028	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.192	-2.794	.008	.003	3	1
UCEC	Notch1 →	+0.207	+2.472	<.001	.010	3	1
UCEC	p90 RSK_pT359_S363 →	-0.202	-3.169	.022	.018	3	1
UCEC	PCNA →	+0.288	+3.169	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

14-3-3_beta by CALR expression — UCEC

Explore this box plot interactively →