CALN1

Across TCGA patient cohorts, CALN1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALN1-associated genes across cancer lineages are STAT3_pY705, p27_pT157, and ACC1. Each is linked with CALN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CALN1-to-partner and partner-to-CALN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by CALN1-low versus CALN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALN1→partner) and Y-score (partner→CALN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.297	-1.574	<.001	.034	3	3
LUSC	p27_pT157 →	+0.087	+3.027	.025	.018	3	2
UCEC	ACC1 →	+0.350	+2.235	.003	.005	3	2
UCEC	JNK2 →	+0.223	+3.727	<.001	<.001	3	2
UCEC	TFRC →	+0.451	+2.000	.010	.029	3	2
UCEC	ASNS →	+0.257	+1.584	.030	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

STAT3_pY705 by CALN1 expression — UCEC

Explore this box plot interactively →