CALML6

Across TCGA patient cohorts, CALML6 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALML6-associated genes across cancer lineages are Shc_pY317, VEGFR2, and MSH2. Each is linked with CALML6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALML6-to-partner and partner-to-CALML6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by CALML6-low versus CALML6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALML6→partner) and Y-score (partner→CALML6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.223	-3.000	.011	.037	3	1
UCEC	VEGFR2 →	+0.436	+3.013	.011	.019	3	1
UCEC	MSH2 →	-0.440	-3.000	<.001	.037	2	1
UCEC	CDK1_pY15 →	-0.253	-2.978	.035	.037	2	1
UCEC	4E-BP1 →	+0.369	+3.000	.018	.037	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Shc_pY317 by CALML6 expression — UCEC

Explore this box plot interactively →