CALML6

Across TCGA cell cohorts, CALML6 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CALML6-associated genes across cancer lineages are PROKR2, GUCA1C, and KRTAP10-6. Each is linked with CALML6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALML6-to-partner and partner-to-CALML6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROKR2 grouped by CALML6-low versus CALML6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALML6→partner) and Y-score (partner→CALML6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PROKR2 →	+0.014	+4.415	<.001	.007	3	1
BREAST	GUCA1C →	+0.616	+5.169	<.001	.005	3	1
BREAST	KRTAP10-6 →	+0.019	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PROKR2 by CALML6 expression — LARGE_INTESTINE

Explore this box plot interactively →