CALML4

Across TCGA patient cohorts, CALML4 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. KIRP shows the largest number of these associations.

The most reproducible CALML4-associated genes across cancer lineages are RNA5SP332, RNU6-902P, and NRON. Each is linked with CALML4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALML4-to-partner and partner-to-CALML4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP332 grouped by CALML4-low versus CALML4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALML4→partner) and Y-score (partner→CALML4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP332 →	+0.268	+7.816	<.001	.008	3	1
KIRP	RNU6-902P →	+0.616	+4.967	<.001	.009	3	1
KIRP	NRON →	+0.121	+5.159	<.001	.007	3	1
KIRP	MIR6765 →	+0.457	+7.124	<.001	<.001	3	1
KIRP	CICP15 →	+0.024	+5.159	<.001	.007	3	1
KIRP	HNRNPCL4 →	+0.075	+5.159	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

RNA5SP332 by CALML4 expression — SKCM

Explore this box plot interactively →