CALML3

Across TCGA patient cohorts, CALML3 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALML3-associated genes across cancer lineages are eIF4E, EGFR_pY1068, and ACC1. Each is linked with CALML3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALML3-to-partner and partner-to-CALML3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CALML3-low versus CALML3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALML3→partner) and Y-score (partner→CALML3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.208	+3.000	.049	.036	3	2
UCEC	EGFR_pY1068 →	-0.335	-2.321	.007	.035	3	1
UCEC	ACC1 →	+0.564	+2.321	.001	.035	3	1
UCEC	PKC-delta_pS664 →	-0.191	-3.160	.001	.019	3	1
UCEC	Shc_pY317 →	-0.198	-2.321	.009	.035	3	1
UCEC	4E-BP1_pT70 →	+0.131	+2.321	.023	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

eIF4E by CALML3 expression — UCEC

Explore this box plot interactively →