CALM2

Across TCGA pan-cancer cohorts, CALM2 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated CALM2 data layer compared with 4 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CALM2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CALM2 expression acts as an unfavorable survival marker, although some lineages such as THCA and LUAD show a favorable association.

ACC, UVM, and LIHC are the cancer types where CALM2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.205	0.715	<.001	123	view →
UVM	DFS	Tertile	III,IV	0.234	0.871	<.001	82	view →
LIHC	OS	Quartile	All	0.535	0.744	<.001	65	view →
HNSC	OS	Median	All	0.185	0.524	.001	45	view →
KICH	OS	Median	II,III,IV	0.637	0.958	.004	44	view →
THCA	OS	Median	III,IV	0.986	0.744	.004	36	view →
PAAD	OS	Tertile	All	0.257	0.519	<.001	35	view →
UCS	DFS	Median	III,IV	0.278	0.576	.003	30	view →
LGG	OS	Median	All	0.753	0.863	<.001	30	view →
BRCA	OS	Tertile	II,III,IV	0.880	0.933	.006	26	view →
UCEC	DFS	Tertile	All	0.774	0.874	.006	26	view →
KIRP	DFS	Tertile	III,IV	0.136	0.606	.002	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

CALM2–ACC (DFS)

Open the ACC breakdown →