CALM2

Across TCGA pan-cancer cohorts, CALM2 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CALM2 data layer compared with 29 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher CALM2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CALM2 expression acts as an unfavorable survival marker.

THCA, BLCA, and LUSC are the cancer types where CALM2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	All	0.071	0.841	<.001	18	view →
BLCA	OS	Median	All	0.212	0.720	.007	12	view →
LUSC	OS	Median	All	0.180	0.675	.030	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CALM2–THCA (DFS)

Open the THCA breakdown →