Across TCGA patient cohorts, CALM1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALM1-associated genes across cancer lineages are 4E-BP1, 14-3-3_beta, and EGFR_pY1068. Each is linked with CALM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALM1-to-partner and partner-to-CALM1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALM1→partner) and Y-score (partner→CALM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.441	+3.730	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.095	-1.973	.012	.029	3	1
UCEC	EGFR_pY1068 →	-0.299	-2.662	.001	<.001	3	1
UCEC	ACC1 →	+0.355	+3.335	.009	.005	3	1
UCEC	Heregulin →	-0.125	-1.807	.007	.025	3	1
UCEC	JNK2 →	+0.239	+2.125	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

CALM1 survival (RNA) · tumor vs normal (RNA) · all CALM1 data types