Across TCGA patient cohorts, CALHM6 protein abundance is significantly associated with the RNA expression of many other genes, with 6,963 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CALHM6-associated genes across cancer lineages are APOL3, IL2RB, and GZMH. Each is linked with CALHM6 in more than 6 cancer types. Because this analysis shows association rather than direction, both CALHM6-to-partner and partner-to-CALHM6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM6→partner) and Y-score (partner→CALHM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	APOL3 →	+1.402	+1.240	.002	.002	3	7
OV	IL2RB →	+1.168	+0.738	.001	.001	3	7
BRCA	GZMH →	+2.012	+1.062	<.001	<.001	3	7
OV	SLA2 →	+1.136	+1.076	<.001	<.001	3	7
BRCA	TLR8 →	+1.282	+1.185	<.001	<.001	3	7
BRCA	TNFSF13B →	+1.269	+1.189	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,963 associations by consensus.

Exploration

CALHM6 survival (RNA) · tumor vs normal (RNA) · all CALHM6 data types