Across TCGA patient cohorts, CALHM6 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALHM6-associated genes across cancer lineages are A-Raf_pS299, FOXO3a_pS318_S321, and Heregulin. Each is linked with CALHM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALHM6-to-partner and partner-to-CALHM6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM6→partner) and Y-score (partner→CALHM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.193	-3.169	<.001	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.201	-3.312	<.001	.010	3	1
UCEC	Heregulin →	-0.151	-2.459	.011	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.239	-3.169	.003	.018	3	1
UCEC	JNK2 →	+0.272	+2.459	.004	.020	3	1
UCEC	mTOR_pS2448 →	-0.181	-3.584	.012	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

CALHM6 survival (RNA) · tumor vs normal (RNA) · all CALHM6 data types