CALHM5

Across TCGA pan-cancer cohorts, CALHM5 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated CALHM5 data layer compared with 19 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher CALHM5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CALHM5 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

LGG and SKCM are the cancer types where CALHM5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.255	0.810	.001	12	view →
SKCM	DFS	Median	All	0.542	0.193	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

CALHM5–LGG (OS)

Open the LGG breakdown →