CALHM5

Across TCGA patient cohorts, CALHM5 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CALHM5-associated genes across cancer lineages are Caspase-7-cleavedD198, Caspase-8, and 4E-BP1. Each is linked with CALHM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALHM5-to-partner and partner-to-CALHM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CALHM5-low versus CALHM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM5→partner) and Y-score (partner→CALHM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.572	+2.827	.038	.035	3	1
UCEC	Caspase-8 →	-0.264	-3.295	.024	.009	3	1
UCEC	4E-BP1 →	+0.328	+3.029	.009	.018	3	1
SKCM	Bak →	+0.237	+3.012	.048	.018	3	1
SKCM	Bcl-2 →	-0.432	-3.169	.026	.019	3	1
UCEC	53BP1 →	+0.360	+3.000	.024	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Caspase-7-cleavedD198 by CALHM5 expression — UCEC

Explore this box plot interactively →