CALHM5

Across TCGA cell cohorts, CALHM5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,324 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CALHM5-associated GO terms across cancer lineages are Regulation of collagen metabolic process, Peptidyl-lysine oxidation, and Regulation of collagen biosynthetic process. Each is linked with CALHM5 in more than 11 cancer types. Because this analysis shows association rather than direction, both CALHM5-to-partner and partner-to-CALHM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of collagen metabolic process grouped by CALHM5-low versus CALHM5-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM5→partner) and Y-score (partner→CALHM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of collagen metabolic process →	+0.146	+0.497	<.001	.001	3	12
BONE	Peptidyl-lysine oxidation →	+1.414	+1.153	<.001	<.001	3	10
CNS	Regulation of collagen biosynthetic process →	+0.131	+1.088	<.001	<.001	3	10
BONE	Positive regulation of cell-substrate adhesion →	+0.195	+1.628	<.001	<.001	3	9
BONE	Regulation of cell-substrate junction organization →	+0.214	+1.585	<.001	<.001	3	9
BONE	Positive regulation of cell-substrate junction organization →	+0.229	+1.356	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,324 associations by consensus.

Regulation of collagen metabolic process by CALHM5 expression — SKIN

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