CALHM5

Across TCGA cell cohorts, CALHM5 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CALHM5-associated genes across cancer lineages are NT5C1A, CST8, and SHISAL2B. Each is linked with CALHM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALHM5-to-partner and partner-to-CALHM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NT5C1A grouped by CALHM5-low versus CALHM5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM5→partner) and Y-score (partner→CALHM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NT5C1A →	+0.054	+4.684	<.001	.002	3	1
LARGE_INTESTINE	CST8 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	SHISAL2B →	+0.331	+4.467	<.001	.004	3	1
LARGE_INTESTINE	SPRR2G →	+0.676	+4.095	.003	.009	3	1
LARGE_INTESTINE	IL25 →	+0.066	+5.562	<.001	<.001	3	1
LARGE_INTESTINE	MS4A6E →	+0.032	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

NT5C1A by CALHM5 expression — LARGE_INTESTINE

Explore this box plot interactively →