CALHM4

Across TCGA patient cohorts, CALHM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,923 significant associations in total. STAD shows the largest number of these associations.

The most reproducible CALHM4-associated GO terms across cancer lineages are Regulation of translational initiation, Vesicle targeting, and Regulation of translation initiation in response to endoplasmic reticulum stress. Each is linked with CALHM4 in more than 14 cancer types. Because this analysis shows association rather than direction, both CALHM4-to-partner and partner-to-CALHM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translational initiation grouped by CALHM4-low versus CALHM4-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM4→partner) and Y-score (partner→CALHM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of translational initiation →	+0.063	+0.060	<.001	<.001	3	14
ESCA	Vesicle targeting →	+0.057	+0.095	<.001	<.001	2	15
STAD	Regulation of translation initiation in response to endoplasmic reticulum stress →	+0.054	+0.066	<.001	<.001	3	14
STAD	Hematopoietic progenitor cell differentiation →	+0.051	+0.061	<.001	<.001	3	13
STAD	Negative regulation of transforming growth factor beta receptor signaling pathway →	+0.047	+0.060	<.001	<.001	3	13
STAD	Protein-containing complex disassembly →	+0.056	+0.062	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,923 associations by consensus.

Regulation of translational initiation by CALHM4 expression — STAD

Explore this box plot interactively →