CALHM4

Across TCGA cell cohorts, CALHM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 369 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CALHM4-associated GO terms across cancer lineages are Regulation of modification of postsynaptic actin cytoskeleton, Ventricular system development, and Serotonin secretion. Each is linked with CALHM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CALHM4-to-partner and partner-to-CALHM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of modification of postsynaptic actin cytoskeleton grouped by CALHM4-low versus CALHM4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM4→partner) and Y-score (partner→CALHM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of modification of postsynaptic actin cytoskeleton →	+0.143	+0.042	.001	.006	3	3
UPPER_AERODIGESTIVE_TRACT	Ventricular system development →	+0.096	+0.029	.001	.007	3	3
SKIN	Serotonin secretion →	-0.745	-0.034	<.001	.001	3	3
SKIN	Regulation of regulated secretory pathway →	-0.034	-0.047	.005	.001	3	3
SKIN	Regulation of SREBP signaling pathway →	+0.065	+0.036	<.001	<.001	3	3
SKIN	Serotonin production involved in inflammatory response →	-0.745	-0.034	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 369 associations by consensus.

Regulation of modification of postsynaptic actin cytoskeleton by CALHM4 expression — UPPER_AERODIGESTIVE_TRACT

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