CALHM2

Across TCGA patient cohorts, CALHM2 protein abundance is significantly associated with the RNA expression of many other genes, with 14,138 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CALHM2-associated genes across cancer lineages are GPT2, TRPV2, and SRPX. Each is linked with CALHM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CALHM2-to-partner and partner-to-CALHM2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CALHM2 versus GPT2 in LSCC, with a Pearson correlation of -0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM2→partner) and Y-score (partner→CALHM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GPT2 →	-0.857	-0.210	<.001	.007	3	3
GBM	TRPV2 →	+0.735	+0.485	.001	.004	3	3
GBM	SRPX →	+1.439	+0.529	<.001	<.001	3	3
GBM	IGFBP7 →	+0.860	+0.482	<.001	<.001	3	3
LSCC	ESRP2 →	-0.587	-0.229	<.001	.001	3	2
GBM	FCGRT →	+0.703	+0.686	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,138 associations by consensus.

CALHM2 vs GPT2 — LSCC

Explore this scatter interactively →