CALHM2

Across TCGA patient cohorts, CALHM2 mutation is significantly associated with the RNA expression of many other genes, with 333 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALHM2-associated genes across cancer lineages are MIR8053, RN7SL148P, and IL3. Each is linked with CALHM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CALHM2-to-partner and partner-to-CALHM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8053 grouped by CALHM2-low versus CALHM2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM2→partner) and Y-score (partner→CALHM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR8053 →	+0.486	+6.342	<.001	.001	3	3
COAD	RN7SL148P →	+0.375	+6.721	<.001	<.001	3	3
COAD	IL3 →	+0.145	+5.357	<.001	.006	3	2
LGG	RNU1-48P →	+0.238	+7.977	<.001	.007	3	2
BRCA	KRTAP21-1 →	+0.129	+5.148	.001	.008	3	2
CESC	RNU6-1214P →	+0.358	+5.306	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 333 associations by consensus.

MIR8053 by CALHM2 expression — CESC

Explore this box plot interactively →