CALHM2

Across TCGA patient cohorts, CALHM2 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALHM2-associated genes across cancer lineages are CD8+ T-cells, Chondrocytes, and NK cells. Each is linked with CALHM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALHM2-to-partner and partner-to-CALHM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by CALHM2-low versus CALHM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM2→partner) and Y-score (partner→CALHM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ T-cells →	+0.013	+2.260	.034	.037	3	2
UCEC	Chondrocytes →	+0.009	+2.801	.001	.002	3	2
STAD	NK cells →	+0.011	+5.597	<.001	.040	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CD8+ T-cells by CALHM2 expression — UCEC

Explore this box plot interactively →