Across TCGA patient cohorts, CALHM1 mutation is significantly associated with the RNA expression of many other genes, with 1,254 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALHM1-associated genes across cancer lineages are LINC01072, GC, and MIR6133. Each is linked with CALHM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CALHM1-to-partner and partner-to-CALHM1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM1→partner) and Y-score (partner→CALHM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01072 →	+0.151	+2.751	<.001	<.001	3	3
SKCM	GC →	+0.953	+4.265	<.001	.003	3	2
HNSC	MIR6133 →	+0.456	+5.655	<.001	.004	3	2
COAD	RNU6-905P →	+0.504	+4.514	<.001	<.001	3	2
COAD	RNU4-27P →	+0.195	+5.149	<.001	.001	3	2
COAD	NDUFA5P5 →	+0.082	+4.332	.006	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,254 associations by consensus.

Exploration

CALHM1 survival (RNA) · tumor vs normal (RNA) · all CALHM1 data types