Across TCGA patient cohorts, CALHM1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALHM1-associated genes across cancer lineages are Heregulin, Mre11, and PCNA. Each is linked with CALHM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALHM1-to-partner and partner-to-CALHM1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM1→partner) and Y-score (partner→CALHM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.136	-3.000	.027	.036	3	1
UCEC	Mre11 →	-0.100	-2.321	.020	.035	3	1
UCEC	PCNA →	+0.269	+3.000	.013	.036	3	1
UCEC	PDK1 →	-0.124	-3.000	.022	.036	3	1
UCEC	Rab11 →	-0.175	-2.321	.016	.035	3	1
UCEC	RBM15 →	+0.325	+2.335	.042	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

CALHM1 survival (RNA) · tumor vs normal (RNA) · all CALHM1 data types