CALD1

Across TCGA pan-cancer cohorts, CALD1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CALD1 data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CALD1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CALD1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LSCC, PDAC, and GBM are the cancer types where CALD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.443	0.811	.004	25	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
GBM	DFS	Quartile	All	0.273	0.540	.006	8	view →
UCEC	OS	Median	II,III,IV	0.647	1.000	.017	4	view →
LUAD	OS	Median	All	0.988	0.934	.018	2	view →
HNSC	DFS	Median	IV	0.588	0.814	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CALD1–LSCC (DFS)

Open the LSCC breakdown →