CALCRL

Across TCGA pan-cancer cohorts, CALCRL mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of CALCRL’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CALCRL mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CALCRL is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

HNSC, LSCC, and LUAD are the cancer types where CALCRL tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CALCRL mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	−0.429	<.001	11	view →
LSCC	Male	All	−1.874	<.001	9	view →
LUAD	Male	II,III,IV	−1.870	<.001	9	view →
CCRCC	Male	All	+0.803	<.001	9	view →
PDAC	All	All	−0.585	.004	3	view →
OV	All	All	−1.017	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

CALCRL–HNSC

Open the HNSC breakdown →