CALCR

Across TCGA pan-cancer cohorts, CALCR Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CALCR data layer compared with 22 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher CALCR Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CALCR expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

ESCA, READ, and THCA are the cancer types where CALCR Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.133	0.708	<.001	36	view →
READ	OS	Median	III,IV	0.375	0.768	.001	22	view →
THCA	DFS	Median	All	0.100	0.841	<.001	18	view →
SKCM	DFS	Median	III,IV	0.764	0.238	.005	10	view →
UCS	DFS	Median	All	0.151	0.529	.048	6	view →
PRAD	DFS	Median	All	0.487	0.777	.026	4	view →
BLCA	DFS	Median	II,III,IV	0.930	0.606	.028	4	view →
UCEC	DFS	Median	II,III,IV	0.882	0.436	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CALCR–ESCA (OS)

Open the ESCA breakdown →