CALCR

Across TCGA cell cohorts, CALCR RNA expression is significantly associated with the go_rna of many other GO terms, with 831 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CALCR-associated GO terms across cancer lineages are Amylin receptor 3 signaling pathway, Positive regulation of post-translational protein modification, and Process utilizing autophagic mechanism. Each is linked with CALCR in more than 14 cancer types. Because this analysis shows association rather than direction, both CALCR-to-partner and partner-to-CALCR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Amylin receptor 3 signaling pathway grouped by CALCR-low versus CALCR-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CALCR→partner) and Y-score (partner→CALCR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Amylin receptor 3 signaling pathway →	+0.494	+0.823	<.001	.001	3	15
LUNG_NSCLC_LUAD	Positive regulation of post-translational protein modification →	+0.032	+0.180	<.001	.006	3	5
LUNG_NSCLC_LUAD	Process utilizing autophagic mechanism →	+0.035	+0.246	<.001	.003	3	5
LUNG_NSCLC_LUAD	Autophagy →	+0.035	+0.246	<.001	.003	3	5
KIDNEY	Proteasomal ubiquitin-independent protein catabolic process →	+0.088	+0.553	<.001	.001	3	4
LUNG_NSCLC_LUAD	Macroautophagy →	+0.035	+0.275	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 831 associations by consensus.

Amylin receptor 3 signaling pathway by CALCR expression — BREAST

Explore this box plot interactively →