CALCR

Across TCGA cell cohorts, CALCR mutation is significantly associated with the RNA expression of many other genes, with 83 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CALCR-associated genes across cancer lineages are TMEM132D, TAS1R2, and CRYBA4. Each is linked with CALCR in more than 1 cancer types. Because this analysis shows association rather than direction, both CALCR-to-partner and partner-to-CALCR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM132D grouped by CALCR-low versus CALCR-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALCR→partner) and Y-score (partner→CALCR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TMEM132D →	+0.138	+4.786	<.001	.001	3	2
LUNG_NSCLC_LUAD	TAS1R2 →	+0.007	+3.604	<.001	.004	3	2
LUNG_NSCLC_LUAD	CRYBA4 →	+0.052	+3.215	<.001	.007	3	2
PANCREAS	CST9L →	+0.041	+4.786	<.001	.001	3	1
PANCREAS	CLEC9A →	+0.706	+4.786	<.001	.001	3	1
PANCREAS	RGS21 →	+0.005	+4.614	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

TMEM132D by CALCR expression — PANCREAS

Explore this box plot interactively →