CALCOCO2

Across TCGA pan-cancer cohorts, CALCOCO2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CALCOCO2 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CALCOCO2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CALCOCO2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, HNSC, and GBM are the cancer types where CALCOCO2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.908	0.530	<.001	64	view →
HNSC	OS	Median	IV	0.972	0.712	<.001	24	view →
GBM	OS	Quartile	All	0.277	0.586	.002	7	view →
UCEC	DFS	Median	All	0.932	0.796	.041	2	view →
LSCC	DFS	Quartile	III,IV	0.528	1.000	.040	2	view →
PDAC	DFS	Tertile	All	0.789	0.650	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CALCOCO2–LUAD (OS)

Open the LUAD breakdown →