CALCOCO2

Across TCGA patient cohorts, CALCOCO2 mutation is significantly associated with the RNA expression of many other genes, with 3,526 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALCOCO2-associated genes across cancer lineages are RNA5SP422, RNA5SP416, and RNA5SP420. Each is linked with CALCOCO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALCOCO2-to-partner and partner-to-CALCOCO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP422 grouped by CALCOCO2-low versus CALCOCO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALCOCO2→partner) and Y-score (partner→CALCOCO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP422 →	+0.655	+2.033	<.001	.001	3	2
UCEC	RNA5SP416 →	+0.522	+2.031	<.001	.003	3	2
UCEC	RNA5SP420 →	+0.472	+2.060	<.001	.002	3	2
HNSC	RNA5SP146 →	+0.336	+5.124	<.001	.008	3	2
LUSC	RNU6-753P →	+0.302	+7.924	<.001	.008	3	2
LUSC	MTND6P17 →	+0.103	+7.924	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,526 associations by consensus.

RNA5SP422 by CALCOCO2 expression — UCEC

Explore this box plot interactively →