CALCOCO2

Across TCGA patient cohorts, CALCOCO2 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALCOCO2-associated genes across cancer lineages are eEF2, EGFR_pY1068, and EGFR_pY1173. Each is linked with CALCOCO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALCOCO2-to-partner and partner-to-CALCOCO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CALCOCO2-low versus CALCOCO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALCOCO2→partner) and Y-score (partner→CALCOCO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.365	+3.459	.009	.005	3	1
UCEC	EGFR_pY1068 →	-0.376	-3.169	<.001	<.001	3	1
UCEC	EGFR_pY1173 →	+0.085	+1.611	.007	.022	3	1
UCEC	eIF4E →	+0.186	+2.335	.024	.018	3	1
UCEC	eIF4G →	+0.335	+2.459	.005	.018	3	1
UCEC	FASN →	+0.418	+1.584	.006	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

eEF2 by CALCOCO2 expression — UCEC

Explore this box plot interactively →