CALCOCO2

Across TCGA cell cohorts, CALCOCO2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CALCOCO2-associated genes across cancer lineages are CHAT, LCE1C, and SLC5A8. Each is linked with CALCOCO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALCOCO2-to-partner and partner-to-CALCOCO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAT grouped by CALCOCO2-low versus CALCOCO2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALCOCO2→partner) and Y-score (partner→CALCOCO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CHAT →	+0.039	+4.688	<.001	<.001	3	1
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10A6 →	+0.044	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CHAT by CALCOCO2 expression — LARGE_INTESTINE

Explore this box plot interactively →