CALCOCO1

Across TCGA patient cohorts, CALCOCO1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALCOCO1-associated genes across cancer lineages are eIF4E, Notch1, and VEGFR2. Each is linked with CALCOCO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALCOCO1-to-partner and partner-to-CALCOCO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CALCOCO1-low versus CALCOCO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALCOCO1→partner) and Y-score (partner→CALCOCO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.168	+3.335	.022	.005	3	2
UCEC	Notch1 →	+0.194	+2.070	<.001	.001	3	2
UCEC	VEGFR2 →	+0.277	+2.115	.007	.016	3	2
UCEC	Caspase-8 →	-0.208	-1.651	.016	.019	3	2
UCEC	Chk2_pT68 →	-0.177	-2.674	.005	.005	3	2
UCEC	eEF2 →	+0.256	+3.169	.039	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

eIF4E by CALCOCO1 expression — UCEC

Explore this box plot interactively →