CALCA

Across TCGA patient cohorts, CALCA protein abundance is significantly associated with the RNA expression of many other genes, with 2,819 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible CALCA-associated genes across cancer lineages are HBP1, OBSCN, and MUC20-OT1. Each is linked with CALCA in more than 1 cancer types. Because this analysis shows association rather than direction, both CALCA-to-partner and partner-to-CALCA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CALCA versus HBP1 in LSCC, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALCA→partner) and Y-score (partner→CALCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HBP1 →	-0.430	-0.646	.004	.003	3	2
LSCC	OBSCN →	-1.122	-0.931	<.001	.004	3	2
LSCC	MUC20-OT1 →	-0.767	-0.762	.004	<.001	3	2
LUAD	FCGBP →	-1.651	-2.426	<.001	<.001	3	2
LUAD	YPEL1 →	-0.442	-1.574	.001	.004	3	1
LUAD	CYTH4 →	-0.437	-1.983	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,819 associations by consensus.

CALCA vs HBP1 — LSCC

Explore this scatter interactively →