CALCA

Across TCGA patient cohorts, CALCA mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALCA-associated genes across cancer lineages are STAT3_pY705, Caspase-7-cleavedD198, and C-Raf. Each is linked with CALCA in more than 1 cancer types. Because this analysis shows association rather than direction, both CALCA-to-partner and partner-to-CALCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by CALCA-low versus CALCA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALCA→partner) and Y-score (partner→CALCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.514	-3.459	<.001	.005	3	1
UCEC	Caspase-7-cleavedD198 →	+0.704	+3.189	.018	.010	3	1
UCEC	C-Raf →	+0.206	+3.000	.004	.036	3	1
UCEC	EGFR_pY1068 →	-0.299	-2.321	.017	.035	2	1
UCEC	eIF4E →	+0.220	+3.459	.038	.005	2	1
UCEC	MEK1 →	+0.490	+2.321	.007	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

STAT3_pY705 by CALCA expression — UCEC

Explore this box plot interactively →