CALCA

Across TCGA cell cohorts, CALCA RNA expression is significantly associated with the go_rna of many other GO terms, with 1,254 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CALCA-associated GO terms across cancer lineages are Negative regulation of calcium ion transport into cytosol, Amylin receptor 2 signaling pathway, and G protein-coupled receptor internalization. Each is linked with CALCA in more than 13 cancer types. Because this analysis shows association rather than direction, both CALCA-to-partner and partner-to-CALCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion transport into cytosol grouped by CALCA-low versus CALCA-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CALCA→partner) and Y-score (partner→CALCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of calcium ion transport into cytosol →	-0.239	-1.604	<.001	<.001	3	14
LUNG_SCLC	Amylin receptor 2 signaling pathway →	+1.073	+5.024	.002	<.001	2	10
LUNG_NSCLC_LUSC	G protein-coupled receptor internalization →	-0.223	-0.907	.005	.004	2	9
LARGE_INTESTINE	Positive regulation of interleukin-1 alpha production →	-0.227	-0.835	.004	.004	2	8
OVARY	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process →	+0.040	+0.458	.002	.005	2	7
KIDNEY	Late endosome to vacuole transport →	+0.089	+0.679	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,254 associations by consensus.

Negative regulation of calcium ion transport into cytosol by CALCA expression — URINARY_TRACT

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