CADPS2

Across TCGA patient cohorts, CADPS2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CADPS2-associated genes across cancer lineages are FOXO3a, HER2, and Ku80. Each is linked with CADPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CADPS2-to-partner and partner-to-CADPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by CADPS2-low versus CADPS2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CADPS2→partner) and Y-score (partner→CADPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FOXO3a →	-0.134	-3.459	.002	.004	3	2
SKCM	HER2 →	+0.264	+2.000	.016	.009	3	2
SKCM	Ku80 →	+0.328	+3.169	.002	<.001	3	2
SKCM	CD31 →	-0.208	-3.305	<.001	.009	3	2
UCEC	MEK1 →	+0.251	+1.847	.023	.007	3	2
UCEC	PDCD4 →	-0.313	-1.238	.028	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

FOXO3a by CADPS2 expression — SKCM

Explore this box plot interactively →