CADPS2

Across TCGA cell cohorts, CADPS2 mutation is significantly associated with the RNA expression of many other genes, with 275 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CADPS2-associated genes across cancer lineages are KDSR, MED9, and WRAP53. Each is linked with CADPS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CADPS2-to-partner and partner-to-CADPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KDSR grouped by CADPS2-low versus CADPS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CADPS2→partner) and Y-score (partner→CADPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KDSR →	+0.825	+3.502	<.001	.001	3	3
BLOOD_Leukemia	MED9 →	+0.725	+3.199	.003	.007	3	2
BLOOD_Leukemia	WRAP53 →	+0.668	+3.199	.002	.007	3	2
BLOOD_Leukemia	DVL2 →	+0.789	+3.199	.003	.007	3	2
BLOOD_Leukemia	DHX33 →	+0.670	+3.199	.002	.007	3	2
CNS	UGT2B11 →	+0.028	+4.643	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 275 associations by consensus.

KDSR by CADPS2 expression — LARGE_INTESTINE

Explore this box plot interactively →