CADM4

Across TCGA patient cohorts, CADM4 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CADM4-associated genes across cancer lineages are PDCD4, Src_pY527, and EGFR_pY1068. Each is linked with CADM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CADM4-to-partner and partner-to-CADM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by CADM4-low versus CADM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CADM4→partner) and Y-score (partner→CADM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.751	-3.459	.001	.005	3	2
UCEC	Src_pY527 →	-0.471	-2.990	.029	.036	3	2
UCEC	EGFR_pY1068 →	-0.285	-2.321	.023	.035	3	1
UCEC	ERK2 →	+0.268	+2.321	.005	.035	3	1
UCEC	GAPDH →	+0.582	+2.999	.030	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.219	-2.308	.009	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PDCD4 by CADM4 expression — UCEC

Explore this box plot interactively →